Friday, July 20, 2012

Magic Conference: Understanding your Pituitary Gland in Health and Disease

MEETING NOTES : Dr. Frohman


Meeting Created: July 20, 2012 9:00 AM

Chicago


Understanding your Pituitary Gland in Health and Disease



Dr. Frohman will present an overview of the pituitary gland. He will cover general aspects of
pituitary function and testing and also review the types of pituitary disease that occur,
including pituitary tumors and Sheehan’s Syndrome. Many people ask and wonder if Growth
Hormone Deficiency can be inherited. Dr. Frohman will also briefly address that concern. 





Pituitary

Sheep studies, pulses pulsatile

GH secretion at night, varies with age.  Most in teens then downhill, follows diurnal rhythm

High igf= cancer?

Hypothalamus
Chris
Anterior pituitary
ACTH
Cortisol
Then back to hypothalamus

Inhibin to inhibit ovary and testes

Types of tumors

Alpha subunit no signs or symptoms 

Microadenoma, macroadenoma

Mass effects
Headache, visual disturbance, neurological damage

Impaired pit function...hypopituitarism

Hypersecretion 

Acromegaly
Hands, feet, facial swelling, sleep apnea, snoring, tall, oily skin, increased soft tissue, Goliath, carpal tunnel
TMJ, osteoarthritis
Metabolic changes
Organ enlargement, hypertension

Cushing's
ACTH, cortisol
Acne, hirsuitism, striae, other usual symptoms

Therapy
Surgery
Drugs keto, mifepristone, pasireotide
Radiation stereotactic, gamma knife can cause hypopituitarism

Hypopituitarism
  • Primary, Sheehan's syndrome uncommon today
  • Genetic
Secondary
  • Trauma
  • Tumor
  • Iatrogenic
  • Traumatic brain injury
  • Anorexia
  • Tumors
  • Steroids
Clinical features
  • Acute
  • Slow
Hypo clinical features

Diagnosis, testing

Q&A

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